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Beating Smoking and Cancer
Men who smoke are approximately 22 times more likely to die of lung cancer, and the risk of heart disease is three times higher in middle-aged men who smoke compared to non-smokers. In addition, people who smoke increase their risk of death from and emphysema by nearly 10 times (a condition in which the lungs’ airways thicken and lose their elasticity with reduced lung tissue). Symptoms are unpleasant and typically , with shortness of breath and a throaty cough being the most common symptoms.
Recent research shows that symptoms of erectile can begin to show in a young man who smokes even before he reaches his 40’s. For middle-aged men, a history of smoking is significantly associated with impotence.
There is also an increased risk of conditions such as Alzheimer’s disease and dementia. According to a recent study by Kaiser Permanente, for two-pack-a-day smokers, the risk was more than doubled. For men smoking one to two packs, the risk increased by 44 percent, and for those who smoked about half a pack a day in mid-life, the risk was increased by 37 percent compared to non-smokers.
If you are a smoker and are trying to quit smoking, it is possible to quit. We are now recruiting individuals to participate in a clinical research study for smoking cessation. We are looking for individuals, both with and without a history of a mental health disorder.
Morningside Recovery
At Morningside Recovery in Newport Beach, CA we offer a unique drug program and mental health center. We focus on Dual- treatment in an effort to solve serious psychological issues that lead to substance abuse and other abnormal behavior.
How long does treatment last?
For primary care, treatment can last 14-28 days. This is not set in stone. We don’t want you leaving our facility if we know you’re not ready and will offer extensions based on individualized feedback from your counselors, family members and peers.
For extended care there is no set time limit for treatment. We offer long term programs for those with severe mental health and substance abuse issues in an effort to get them clean once and for all. The key lies in the support and life changing habits we teach at our facility.
What types of substance abuse do you treat?
Morningside Recovery treats all types of drug and alcohol abuse. We have seen it all and adapt our programs to fit the individual needs of our clients. Through the breakthrough efforts provided by dual-
A new research shows “Resveratrol” in red wine stops breast cancer cells from growing
Breast cancer can affect women and even men of all ages. It is an extensive disease in which cells in the breast tissue separate and grow without normal control.
A team of researchers at University of Calabria in Italy suggests that “Resveratrol” the healthy ingredient found in red wine can stop breast cancer cells from growing by blocking the growth effects of estrogen.
Resveratrol found in the skin of red grapes and in other fruits can prevent the female hormone oestrogen and is able to counteract the malignant progression. It proves to be a useful treatment for the women with breast cancer whose tumors eventually develop resistance to hormonal therapy.
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Sebastiano Ando was involved in the research and said, “Resveratrol is a potential pharmacological tool to be exploited when breast cancer become resistant to the hormonal therapy.”
During the research, several breast cancer cell lines expressing the estrogen receptor were used to test the effects of resveratrol. Some of the cells were treated with resveratrol and some cells were left untreated to compare. The reduction in cell growth was fund in treated cells which was due to a drastic reduction of estrogen receptor levels caused by resveratrol.
Researcher’s stated that Red wine is beneficial to our health but that does not mean people should start using red wine or resveratrol supplements as a treatment for breast cancer. It is recommended that all men and women over the age of 20 should perform a breast self-exam once a month to detect any problems as early as possible.
Research: Number Of Male Breast Cancer Cases Are on Rise and Needs More Awareness
Male breast cancer is rare and for only about 1% of all breast cancers.
Awareness of male breast cancer is low and many of them don’t even realize that they are at risk. When they do get the disease, it is often at more advanced stage. This reveals that men are at risk and needs more awareness.
A lump beneath the nipple is the most common symptom and infiltrating is the most common type of male breast cancer.
The cause of the male breast cancer has not been fully characterized, but the cancer risk in men is increased by elevated levels of estrogen, previous radiation exposure and a family history.
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Dr Valerie Speirs who did a research at University of Leeds said, “Pinpointing an exact cause for this increase is difficult. Lifestyle changes over the latter decades of the 20th century, leading to increased obesity, physical inactivity and development of a binge drinking culture may be contributing factors. Some of the same inherited genetic changes that increase the risk of women developing breast cancer are also thought to influence risk in men.”
Another study reveals men
Dr. Mikael Hartman (a professor at the National University Cancer Institute in Singapore) says, “We believe that men present later due to limited awareness of the disease, so that men who develop a breast lump delay seeing their doctor longer than a comparable woman would with similar symptoms.”
“The outcomes of men have improved over time, but not to the same extent as for women”, he added. The study concluded: Men need to get the right information, treatment and emotional support.
Treating Early Stage Breast Cancer with Herceptin and Chemo
UCLA’s Jonsson Comprehensive Cancer Center research shows that treatment with a combination of the molecularly targeted drug Herceptin and significantly increases survival in women with early stage breast cancer.
According to Dr. Dennis Slamon whose laboratory and clinical research led to the development of Herceptin, the drug Adriamycin which is commonly used as a mainstay to treat breast cancer should be avoided as it cannot treat early stage breast cancer effectively and can cause permanent heart damage.
“We are encouraged that the survival advantages found in this study have been maintained and continue to be significant. I believe there’s room for even further improvement, “said Dennis Slamon.
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The study compared the standard therapy of Adriamycin and which was followed by Taxotere (ACT), the same regimen plus one year of Herceptin (ACTH) and a regimen of Taxotere and
He said this is done for the first time in population of breast cancer patients that overall survival has been measured a little more than five years.
HER-2 positive breast cancer is more aggressive, it also results in a poor prognosis and shorter survival. For women with HER-2 positive breast cancer Herceptin is proved to be effective.
The study was conducted with the motive to find the , but it also measured overall survival and safety including cardiac toxicities, pathologic, molecular markers and quality of life. This study also suggests that the present and future is clearly brighter for patients with HER-2 positive breast cancer.
More on breast cancer cures and how you can contribute to it.
Study: Bone drug “zoledronic acid” could prevent and treat bone loss in breast cancer patients
A study reveals that Zoledronic acid bone drug protects against the bone damaging side effects of certain breast cancer medications like aromatase inhibitors. Zoledronic acid is an injectable drug belonging to a class of drugs called bisphosphonates with trade names Aclasta, Blaztere Inj Vial, Cytozol Vial, Zifonate Vial, Zobone, Zolasta Vial, and Zoldonat Vial. It is also approved by the U.S. Food and Drug Administration for conditions including osteoporosis and bone complications of cancer.
Zoledronic acid which is primarily used for prevention and treatment of osteoporosis in men and postmenopausal women is also used for Paget’s disease and osteoporosis caused by steroid treatment. It reduces the amount of calcium released from the bones into the blood. Patients who are allergic to this drug, suffering with paralysis condition, during pregnancy and lactation should avoid this drug.
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Many postmenopausal women with are routinely treated for several years with aromatase inhibitors which can cause bone loss and fractures. Adam Brufsky did a five-year study called “Z-FAST” to see if the bone drug zoledronic acid could prevent and treat bone loss in postmenopausal
Dr. Adam Brufsky said, “This study shows that bone loss from aromatase inhibitors can be prevented long term with a safe and effective drug that prevents osteoporosis.”
The most common side effects of zoledronic acid are fever, muscle pain, joint pain, headache, arthralgia and pain in hands and feet.
Researchers identified p38-gamma molecule to check aggressive breast cancer
Researchers at the University Of Michigan Comprehensive Cancer Center have identified a specific molecule (p38-gamma) that affects the ability of cells to spread or metastasize to distant parts of the body.
They found that the p38-gamma molecule controlled how quickly and easily a cancer cell moved and if it (p38-gamma) was inactivated, cells flattened out and changed from fast motion to an ineffective movement.
Sofia Merajver, author leading the study said, “Normal motion is commonly seen in aggressive cancers, which is why it’s very important to understand what the key switches are for this motion.”
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From previous study Merajver found that the cancer gene RhoC promotes aggressive metastasis and following that pathway her team now identified the p38 molecule that controls the cells to make them so aggressive. The p38 molecule is found in particular p38-gamma, has several different types and is highly expressed in aggressive breast cancer.
According to the researchers, identification of p38-gamma in provides a strong target for potential new therapies and they will be able to develop a drug that targets only p38-gamma without affecting other pathways, making it more tolerable for patients.
Sofia Merajver says, “We do have targeted therapies in the clinic, but the total burden of disease that they ameliorate is still relatively minimal. The reasons may not necessarily be that they are not good drugs, but simply that we don’t understand how they work, because we don’t understand the biology in sufficient detail. That’s why studies like this are so important in advancing drug development.”
Breast Cancer Prognosis
A prognosis is an estimate of rate for the patients with similar classification. It is usually calculated as an average number of years a patient can survive for. The classification and the prognosis for breast cancer generally depend on its stage, grade, recurrence of the disease, the age of the patient and health of the patient.
The five stage of the breast cancer highly affects the prognosis.
• Stage 0 - in situ. No tumor is regional lymph nodes and no distant metastases. The five-year survival for Stage 0 is 99%.
• Stage I - Tumor is less than or equal to 2 centimeters, No tumor is regional lymph nodes, No distant metastases. The five-year survival for Stage I is 92%.
• Stage IIA – There are three sub-stages of tumor in Stage IIA:
1. No evidence of primary tumor, metastases to movable ipsilateral nodes, No distant metastases.
2. Tumor is less than or equal to 2 centimeters, metastases to movable ipsilateral nodes, No distant metastases.
3. Tumor is between 2 and 5 centimeters, No tumor is regional lymph nodes, No distant metastases.
The five-year survival for Stage IIA is 82%.
• Stage IIB - There are two sub-stages of tumor in Stage IIB:
1. Tumor is between 2 and 5 centimeters, metastases to movable ipsilateral nodes, No distant metastases.
2. Tumor is over 5 centimeters, No tumor is regional lymph nodes, No distant metastases.
The five-year survival for Stage IIB is 65%.
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• Stage IIIA - There are four sub-stages of tumor in Stage IIIA:
1. No evidence of primary tumor, metastases to fixed ipsilateral nodes, no distant metastases.
2. Tumor is less than or equal to 2 centimeters, metastases to fixed ipsilateral nodes, No distant metastases.
3. Tumor is between 2 and 5 centimeters, metastases to fixed ipsilateral nodes, no distant metastases.
4. Tumor is over 5 centimeters, metastases to movable or fixed ipsilateral nodes, no distant metastases.
The five-year survival for Stage IIIA is 47%.
• Stage IIIB - There are two sub-stages of tumor in Stage IIIB:
1. Tumor extends to , any nodal involvement, no distant metastases.
2. Any primary tumor involvement, metastases to ipsilateral internal mammary nodes, no distant metastases.
The five-year survival for Stage IIIB is 44%.
• Stage IV - Any primary tumor involvement, any nodal involvement, distant metastases. The five-year survival for Stage IV is 14%.
The researchers at Wake Forest Baptist Medical Centre have identified 16 new genes connected with breast cancer. The focus of the team’s future research is to provide better prognostic information about breast cancer.
Diagnosis of Breast Cancer
Breast cancer cannot be detected with the naked eye always and the symptoms vary from person to person. Changes to your breasts like change in breast skin texture, skin rash, skin dimpling, new lumps and bumps found always may not be the result of breast cancer. It may be the result of non-cancerous conditions like your age, hormonal changes, an infection or a cyst.
To know whether a lump, bump, skin rash or skin dimpling is or cancerous, you will need help from your medical professionals for a clear diagnosis. Generally, this process of diagnosis takes time and involves many different kinds of tests.
Clinical Breast Exam (CBE)
If you are over 40 years of age and if you experience any breast changes, you should visit your doctor. Breast self-exam should be part of your monthly health care routine. If any irregularities are found, a mammogram and ultrasound should also be done by a doctor to clarify the problem.
A radiation oncologist at Forrest General Hospital’s Cancer Center, Dr. Naim Salloum encourages women to do monthly self breast exams and have a yearly examination.
He says, every women at age of 40 should start having a mammogram every year. Early detection helps saving lives.
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Mammograms
A mammogram is the standard screening and early detection for breast cancer and can help detect 85- 90% of all breast cancers, even before you can feel a lump.
Breast Magnetic Resonance Imaging (MRI)
It can be used as a complementary test that reveals different details of your breast health than a mammogram.
Elastography
Elastography is a new technology for imaging breast tissue which can find a cancerous lump without a biopsy.
Pathology Tests
A sample of tissue or fluid is taken and tested by a pathologist if needed.
Tissue Tests
A very small tissue sample from your breast is removed for test and is examined under a microscope for cancer.
Genetic testing
and are human genes linked to hereditary breast and ovarian cancer.
The treatment options for women include a lumpectomy or mastectomy which depends on knowing characteristics like the size and appearance of the cancer, its growth and signs of spreading to nearby healthy tissues, hormones or genetic mutations.
Once you understand your condition you can consult your doctor and make better decisions. If the breast cancer is found and diagnosed early, the better are the chances of beating it.
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Beating Smoking and Cancer
Morningside Recovery
A new research shows "Resveratrol" in red wine stops breast cancer cells from growing
Research: Number Of Male Breast Cancer Cases Are on Rise and Needs More Awareness
Some Information About Lung Cancer (2)
Smoking Can Cause Lung Cancer (1)
Breastfeeding - While Getting Sleep (1)
False Positives Higher with Breast Exam than with Mammography (1)
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